Saturday, February 9, 2013

Colon cancer exhibits a corresponding epigenetic pattern in mice and humans

Feb. 7, 2013 ? Tumourigenesis is driven by genetic alterations and by changes in the epigenome, for instance by the addition of methyl groups to cytosine bases in the DNA. A deeper understanding of the interaction between the genetic and epigenetic mechanisms is critical for the selection of tumour biomarkers and for the future development of therapies. Human tumour specimens and cell lines however contain a plethora of genetic and epigenetic changes, which complicate data analysis. In contrast, certain mouse tumour models contain only a single genetic mutation and allow the analysis of nascent tumours.

Scientists of the Max Planck Institute for Molecular Genetics in Berlin have now discovered a recurring pattern of more than 13,000 epigenetic alterations in young tumours of the mouse. This genome-wide pattern was found to be partly conserved in human colon carcinoma, and may therefor facilitate the identification of novel clinical colon cancer biomarkers for early detection.

Two kinds of molecular changes are known to trigger tumour development: one is genetic mutations -- i.e. alterations in the alphabetic sequence of the DNA -activating genes that lead to uncontrolled growth of tumours, or inactivating genes that inhibit this growth. The other is epigenetic modifications, for example new distributions of methyl groups in the DNA that contribute to the genetic information in the cancer cells being interpreted differently.

Genetic and epigenetic mechanisms work together in cancer development -- but little was known about how these systems mutually influence one another, and which changes first come to light. These questions can only be answered with great difficulty through investigating human tumours: the cancer is usually already several years old when diagnosed. Accordingly, the cancer cells already exhibit thousands of genetic and epigenetic changes at this stage, which complicates the analysis.

The matter is different for the corresponding polyps in mice, which the researchers can investigate considerably earlier following their formation. For this reason, scientists of the Max Planck Institute for Molecular Genetics have now pursued the question of which epigenetic changes in intestinal tumours occur first with the help of a mouse model. "With mice, we can investigate the first changes much more easily than with humans," says Markus Morkel, who led the study. The scientists analysed the epigenetic changes in a strain of mice with a defective copy of the APC gene. This gene serves as an intestinal tumour suppressor in mice as well as in humans. Accordingly, it has lost its functionality in a majority of patients with colon cancer.

The results displayed a clear picture: The researchers recognised a recurring pattern of more than 13,000 epigenetic changes in all of the mouse tumour samples. By contrast, they did not find this pattern in healthy intestine or in intestinal stem cells, which are the cells of origin of the tumour. Since the mice -and hence the tumours- were less than three months old, the changes must have already spread shortly after the first genetic mutation in the APC gene within the tumour cells. According to the scientists, the first mutation already leads to pathological activation of numerous enzymes controlling the epigenetic mechanisms.

Remarkably, the molecular biologists discovered large parts of the tumour-specific epigenetic pattern not only in the mouse, but also in human colon cancer tissue. "These initial epigenetic changes could therefore serve as markers and significantly simplify the early diagnosis of colon tumours in the future," hopes Markus Morkel. Patients would merely have to provide a blood sample for the diagnosis and could forego an enteroscopic procedure.

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Story Source:

The above story is reprinted from materials provided by Max-Planck-Gesellschaft.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Christina Grimm, Lukas Chavez, Mireia Vilardell, Alexandra L. Farrall, Sascha Tierling, Julia W. B?hm, Phillip Grote, Matthias Lienhard, J?rn Dietrich, Bernd Timmermann, J?rn Walter, Michal R. Schweiger, Hans Lehrach, Ralf Herwig, Bernhard G. Herrmann, Markus Morkel. DNA?Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer. PLoS Genetics, 2013; 9 (2): e1003250 DOI: 10.1371/journal.pgen.1003250

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/rWsOQAz4qWo/130207172100.htm

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Mesothelioma Cancer

Mesothelioma is an aggressive cancer affecting the membrane lining of the lungs and abdomen

Malignant mesothelioma?is the most serious of all asbestos-related diseases. Although uncommon, mesothelioma cancer is no longer considered rare. The primary cause and risk factor for mesothelioma is exposure to asbestos.

Making a correct?mesothelioma diagnosis?is particularly difficult for doctors because the disease often presents with symptoms that mimic other common ailments. There is no known cure for mesothelioma, but treatments such as surgery and chemotherapy have helped to improve the typical?mesothelioma prognosis.

Pleural mesothelioma?(affecting the lung?s protective lining in the chest cavity) represents about three quarters of all mesothelioma incidence.?Peritoneal mesothelioma?which affects the abdominal cavity and?pericardial mesothelioma, which affects the cardiac cavity, comprise the remainder. Testicular mesothelioma is extremely rare and typically presents with metastases of the peritoneal variety. There are three recognized mesothelioma cell-types. Between 50 and 70% of all mesotheliomas are of the epithelial variety. While prognosis is generally poor, it is considered less aggressive than sarcomatoid mesothelioma and biphasic mesothelioma, which comprise the remainder of cell type diagnoses.

The cavities within the body encompassing the chest, abdomen, and heart are surround by a membrane of cells known as the mesothelium. Mesothelial cells assist in general organ functions. The mesothelium is particularly important to organs that are commonly in motion, such as expansion or contraction of the lungs, stomach, or heart. Lubrication from the mesothelial cells allows free range of motion within the body. The mesothelium of the chest, abdomen, and cardiac cavity are called the pleura, the peritoneum, and the pericardium, respectively. Each of these groupings of mesothelial cells are extremely critical to the functions of the body structures which they encompass.

Malignancies (cancerous tumors) occurring within the mesothelial membranes are known as malignant mesothelioma, or simply mesothelioma. Benign tumors of the mesothelium are known to occur, but are much rarer than the more common malignant cancer.

While?tumors?of the mesothelium were first recognized in the late 18th century, it was not until the middle of the 20th century that this particular cancer was studied and examined with more detail. It was at this time where suspicions of the cancer?s causal relationship with?asbestos exposure?became more substantiated. A joint?research?venture through the Department of Thoracic Surgery at the University of the Witswater and/Johannesburg General Hospital in South Africa provided the most compelling evidence of the nexus between asbestos exposure and the development of pleural mesothelioma.

Incidence of mesothelioma is still quite rare, with only 2,500-3000 diagnoses in the United States each year. There was a spike in reported diagnoses between 1970 and 1984, which has been attributed to the latency period between diagnosis and the height of industrial exposures, which occurred roughly 40-60 years prior to this time. Exposure was common in nearly all industries but was particularly common in the WWII-era military industrial cycle, including?Navy Shipyards.

Although this cancer is much more common in men over the age of 60 (largely attributed to the industrial exposures within male-dominated industries), mesothelioma in women and children has been described as well.?Mesothelioma causes?for diagnosis in women and children are mainly attributed to secondary exposure to asbestos, as it was not uncommon for men to bring asbestos back into the home on their body or clothing if proper cleaning facilities were not available on site.

Mesothelioma is diagnosed through a comprehensive combination of biopsy and imaging scans.

Mesothelioma can be a difficult malignancy to diagnose because the symptoms and pathology of the disease closely resemble other respiratory conditions. For this reason, misdiagnosis is not uncommon in mesothelioma patients.?Symptoms of mesothelioma?include chest pain, chronic cough, effusions of the chest and abdomen, and the presence of blood in lung fluid.

Diagnostic surgeries, including a biopsy, will typically be required to determine the type of malignant cells that are present in the body. Typically a body imaging scan, including a magnetic resonance image (MRI) or computer topography (CT scan) will be required to determine the extent and location of the disease.

Mesothelioma patients are generally referred by their personal physicians to one of the many renowned mesothelioma?doctors?in the United States. These?oncologists?are well versed in the disease behavior and pathology and are the most familiar with cutting-edge mesothelioma treatment options.?Dr. David Sugarbaker?of the Brigham and Women's Hospital, an extension of Harvard University and the Dana Farber Cancer Institute in Boston, MA, is at the forefront of mesothelioma treatment through the International Mesothelioma Program.

While mesothelioma is typically advanced at diagnosis, treatment options are available.

Mesothelioma, while certainly an aggressive?disease, is a manageable malignancy. While there is no cure for the cancer,?mesothelioma treatment?options including surgery, chemotherapy, and radiation therapy are available for many patients. While a combination of Alimta? and Cisplatin is currently the only FDA approved chemotherapy regimen, several clinical trials are currently in progress utilizing other drugs including Gemcitabine and Onconase, with many showing dramatically improved results in certain cancer patients.

Radiation therapy is also utilized, but typically in conjunction with other treatment methods like surgery and chemotherapy. Surgical resection of mesothelioma is possible in early-stage-diagnosed patients. Aggressive surgeries such as extrapleural pneumonectomy can extend survival rates far beyond previously-thought timeframes. Diagnostic and palliative surgeries such as pleurocentesis and pleurodesis are also common in patients of malignant mesothelioma cancer.

Alternative therapies have also been used effectively by many mesothelioma patients to assist in managing symptoms of the disease and conventional treatments. These treatments are mainly preferential but can be extremely valuable to many patients.

Mesothelioma is caused by exposure to asbestos.

Mesothelioma is only caused by exposure to asbestos, though cases have been documented in children or other individuals with no asbestos history. Asbestos is a microscopic and naturally-occurring mineral that lodges in the pleural lining of the lungs and the peritoneal lining of the abdominal cavity. In most cases, several years will pass (up to 60) before mesothelioma develops in those who had been exposed to asbestos.

In many cases, those individuals diagnosed with mesothelioma that have been known to be exposed to asbestos may be eligible for financial compensation from asbestos manufacturers for their illness. Those who have been diagnosed with mesothelioma and were exposed to asbestos should fill out the brief form on this page. We'll rush you a complimentary mesothelioma and asbestos exposure information kit detailing new mesothelioma treatments, active clinical trials, top doctors, as well as how to obtain compensation for asbestos-related health conditions like mesothelioma.

http://www.mesothelioma.com/mesothelioma/

Source: http://www.rjeem.net/2013/02/mesothelioma-cancer.html

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Friday, February 8, 2013

CIA nominee Brennan in hot seat before Senate

John Brennan, the White House nominee to head the CIA, faced a series of questions during his Senate Intelligence Committee hearing on Thursday regarding how he would lead the organization, and was pressed on agency leaks of national security information under President Barack Obama as well as on interrogation techniques like waterboarding.

Brennan, a gruff 25-year CIA veteran and the White House's counterterrorism adviser, was also questioned about the use of drone strikes.

Brennan got a bit of help late on Wednesday on the issue of drone strikes from Obama, who directed the Justice Department to share with the Senate and House Intelligence Committees several classified memos laying out the legal rationale for the strikes, notably those that target Americans. Some of the Senate committee?s eight Democrats and seven Republicans had suggested they might block Brennan's nomination until the administration made those documents available.

The issue had attracted fresh scrutiny this week when NBC News obtained and published a 16-page white paper that gives the green light for targeting individual Americans anywhere outside the U.S. for assassination ? without oversight from Congress or the courts, and even if the U.S. citizen in question is not actively plotting a specific terrorist attack.

The White House on Tuesday defended targeted assassinations as ?necessary,? ?ethical? and ?wise.? Human rights and civil liberties groups have condemned those strikes partly because they are carried out without such oversight. Other critics have warned that civilian deaths in drone strikes inflame anti-U.S. sentiment and help Islamist extremist groups recruit new members.

Brennan defended the use of drone strikes against terrorists, but said he preferred catching them alive.

?I never believe it?s better to kill a terrorist than to detain him," he said, added there was value in interrogating suspects.

Regarding information leaks, Republicans have charged that the Obama administration has disclosed sensitive information for political gain. The White House denies this. When pressed by North Carolina Sen. Richard Burr about the information he makes public, Brennan denied revealing classified information from covert operations.

"I know the importance of keeping those secrets secret," he said.

Brennan also faced questions about how he opposed Bush administration ?enhanced interrogation techniques??practices like waterboarding that the United States used to label torture. He has said in the past that, while at the CIA, he objected to that program. He told the committee that he believe waterboarding "should not be done" and "never will be" used under his direction.

In a pre-hearing submission to the committee, Brennan said he ?did not play a role in its creation, execution or oversight? and ?had significant concerns and personal objections? that he expressed ?privately? to colleagues at the agency. Brennan will tread carefully: He withdrew his name from consideration to head the CIA four years ago in the face of opposition from liberal groups who charged that he had not done enough to oppose such interrogations. And Republican Sen. John McCain, who survived torture as a prisoner of war in Vietnam, released a letter late Wednesday openly doubting that Brennan put up much of a fight.

At the beginning of the hearing, protestors from the anti-war group Code Pink interrupted the proceedings, and were immediately escorted out of the committee room. "We're making more enemies," one demonstrator shouted, referring to the United States' ongoing military campaigns abroad. Other protesters continued to interrupt the hearing before committee Chairman Sen. Dianne Feinstein, Democrat of California, ordered the room cleared.

Source: http://news.yahoo.com/blogs/ticket/cia-nominee-brennan-faces-tough-questions-confirmation-hearing-093053057--politics.html

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Potential MLP Tax Rule Changes Aren't That Taxing | iStockAnalyst ...

(By
Connie Hsu, CFA and Jason Stevens) The
Alerian MLP Index sold off nearly 7% in mid-November after the
presidential election, as concerns about the fiscal cliff, budget
deficit, and changes to favorable tax regulations took hold. Beyond
marketwide concerns about pending dividend and capital gains tax
increases, master limited partnership investors seemed concerned that
MLPs may be subject to corporate taxes and new carried interest rules.
These threats--which have existed for years--have been amplified lately
by fears regarding the drastic measures needed to resolve the federal
government's budgetary woes. MLPs, which do not pay taxes at the entity
level, look to be an easy revenue target, but we believe it is highly
improbable that they will see any major changes to their tax-favored
status. In the unlikely event that MLPs became subject to corporate
taxation, however, we'd expect only a modest impact on valuations.

Removal of Congressional Support Unlikely
Master limited partnerships have enjoyed pass-through tax status since the Tax Reform Act of 1986, which was designed to encourage private investment through a lower cost of capital. MLPs pass through their income to unitholders, who then pay taxes on that income at their own marginal tax rates often only when the units are sold. MLP income is therefore taxed only once, in contrast to the double taxation that happens when corporations pay entity-level taxes on income and shareholders pay a second layer of taxes on dividends received.

MLP investors therefore pay less tax overall, but the difference is not significant enough for the government to pursue, in our view. In early 2012, Congress estimated that taxing energy MLPs (with a combined market capitalization of more than $300 billion) at the corporate tax rate of 35% would generate only $300 million in annual revenue. The low tax yield is largely due to the nature of midstream businesses (which constitute the majority of MLPs); they employ heavy fixed assets that garner a large depreciation deduction in the calculation of taxable income. Because the gain is trivial relative to other potential tax revenue sources, we do not believe Congress will pursue this route.

Moreover, additional taxation would jeopardize private investment in the development of domestic energy resources and potentially force even costlier public investment over the long term. MLPs have gained bipartisan support, as they have proved very successful in financing and building out energy infrastructure over the years, in line with many political agendas that seek lower energy costs for consumers, domestic energy independence, and jobs growth. In recent congressional testimony, the National Association of Publicly Traded Partnerships, the industry lobbying body, noted that MLPs supported an estimated 323,000 jobs in the midstream energy sector and invested an estimated $17 billion in domestic energy infrastructure during 2011.

To this end, the most recent changes to MLP tax rules have actually expanded the potential base for MLP qualifying income to include transportation and storage of biofuels and other liquids, in support of their development. Likewise, the latest MLP proposal (the Master Limited Partnerships Parity Act introduced this past June) targets further expansion of the MLP umbrella to include renewable energy activities, while the latest fiscal cliff deal (the American Taxpayer Relief Act) extends and increases tax subsidies worth an estimated $12 billion over 10 years to wind energy companies.

What Could Change in the Short Term?
Of all tax reforms, the two most likely are changes to the treatment of dividends/capital gains and carried interest.

The just-passed American Taxpayer Relief Act increases the dividends/capital gains tax rate for high earners (annual household income of greater than $450,000) to 20% from 15%. Over time, this higher tax rate could apply to a larger population if the income threshold is lowered to the originally proposed $250,000. Broadly speaking, the higher the dividend taxes, the more attractive the tax-deferred status of MLPs appears to investors, when compared with corporations. Because distributions are not taxed as dividends, MLP investors pay less in total taxes on net income.

We do not believe treatment of carried interest in publicly traded partnerships will affect energy MLPs at all, as the proposal targets financial services firms that are structured as publicly traded partnerships. Carried interest refers to the share of profits that partners receive for profitable investments, which under partnership taxation rules is taxed at the long-term capital gains rate. It's been an issue lately because hedge fund and private equity managers, who receive much of their compensation through this carried interest, effectively pay only lower capital gains taxes on this compensation, rather than higher ordinary income taxes. Proposed legislation seeks to treat the carried interest of financial services firms as ordinary income. Though this does not affect MLPs generally, it could have some impact on publicly traded general partnerships, as incentive distribution rights could become taxable as compensation and hence be subject to ordinary income taxes. However, the language of the current bill specifies these changes for financial services firms, so energy MLPs would be excluded. Additionally, MLP unitholders already pay taxes at full ordinary income tax rates. Hence the potential revenue gain for the government from corporate taxes comes at the expense of losing the taxes that partnership unitholders currently pay. This is another reason the incremental gain of taxing MLPs is less than expected at first glance.

What Could Change Over the Long Term?
Over the long term, we believe a greater overhaul of tax policy is fully possible. Potential changes could take several very different flavors, affecting both corporations and MLPs. There are several proposals that we believe would significantly affect MLP investors, including shareholder credits for corporate taxes paid; corporate deductions for dividends paid; shareholder exemptions for dividends received; rate alignment (investor tax rates on dividends and capital gains on sales of corporate stock would be reduced as a partial offset to the additional tax at the entity level); and lowering the maximum corporate tax rate while broadening the tax base applicable to the tax.

While we cannot precisely show the impact of each proposal, we note that overall these efforts seek to eliminate or reduce the double taxation of corporate profits at the entity level and shareholder level. Should such reforms pass, the tax revenues from MLPs and corporations would therefore be much more comparable.

Valuation Impact to Morningstar's MLP Coverage

Though we view the probability as remote, it is possible that the MLP structure could be eliminated. It is difficult to precisely forecast the impact to the sector without knowing the specifics, but to get a sense of how valuations and structures could change, we make a few simplifying assumptions to generate a worst-case scenario.

We assume the MLP structure dissolves, businesses convert to corporations, and income is subsequently subject to corporate taxes at the 35% statutory rate. However, the C-corps under our midstream coverage realize an average effective tax rate of 25%, and hence we use a 25% effective tax rate in this scenario. We assume Congress provides a grace period, comparable to historical precedent of three to four years (depending on when the legislation is passed), so corporate taxation begins in 2016.

This higher tax rate is somewhat offset by the lower implied weighted average cost of capital. The taxes paid now reflect an interest tax shield previously unrealizable for MLPs. We maintain the capital structure mix of about 50% debt financing and 50% equity financing in this WACC assumption and in our financial forecasts through 2016. Realistically, we'd expect companies to shift toward greater use of debt financing over time, but for our simplified scenario, we maintain the current mix.

In our discounted cash flow models, we reduced terminal enterprise value/EBITDA multiples by 2 full turns to reflect the average premium at which midstream MLPs currently trade to midstream C-corps. We attribute the premium primarily to the structural tax and capital cost differences between MLPs and corporations, which we extract in this scenario.

We assume that general partners of MLPs dissolve as soon as administratively possible, probably before corporate taxes begin in 2016. This could happen in several ways--through the conversion of GP units to LP units, a cash buyout of the GP, or vice versa. For our worst-case scenario, we assume the first option, that GP units convert to LP units at revised fair value estimates after applying taxes in perpetuity and a lower WACC. In reality, this unit conversion may not take place at fair values, but instead at a discount to market pricing upon announcement. This therefore implies that publicly traded general partners dissolve after receiving LP units as compensation. In our coverage universe, this applies to NuStar GP Holdings and Energy Transfer Equity.

Assuming a gradual shift to corporate status, we'd expect distributions to be cut dramatically, as capital structures shift to reduce reliance on the capital markets for growth financing (a hallmark of the MLP model). With lower expected free cash flow, firms would probably slow expansion and hold on to more free cash flow in order to internally finance growth, rather than routinely issue follow-on equity, in particular. This would curb growth expectations (from current average annual growth rates of about 5%) making these former MLPs less attractive to yield investors.

Our worst-case scenario does not incorporate these growth factors, as we believe they are strategy changes that are likely to vary significantly, depending on company-specific considerations such as existing capital structures and growth prospects.

Given our simplification of the MLP transition process, our estimates should be taken with a large heap of salt. However, we still find the exercise interesting for a few reasons. In particular, we were able to derive some general observations about what types of MLPs would see the most impact and the least, which provides some insight into current capital costs across our coverage universe. This type of comparison is not easily observed because of the different MLP structures in existence, given the range of general partner incentive distribution rights, international taxes, subordinated unit issuances with particular rights, and excess cash flow cushions. In particular, this taxation exercise effectively removes a major difference in capital structures (general partner incentives) and puts capital costs on a more level (albeit still uneven) playing field.

In this tax-affected scenario, the impact is significant but not devastating by any means. Our fair value estimates fall an average 14% as a result of corporate taxation, and we observe a few trends.

A lower weighted average cost of capital benefited all companies modestly, adding an average 4% to fair value estimates. On average, our WACCs decreased by 70 basis points, to 7.3%, thanks to the inclusion of tax shield benefits.

Raising the effective tax rate by 25% hurt valuations by an average 18% across the board, as a result of lower free cash flow in perpetuity. This makes intuitive sense, since for our coverage approximately 80% of discounted cash flows lie in the perpetuity. As our exercise does not apply taxes to cash flows generated through 2015, we'd expect less than a 25% hit to valuations.

For the MLPs with general partners, eliminating the GP burden generally improved valuations, as some of the tax hit was absorbed by lower GP stake valuations.

Historical Precedents Offer Clues
Though we cannot forecast firm or market reactions to tax changes with much certainty, there is some historical precedent regarding how similar tax legislation changes affected business organizations and the subsequent market reaction. First, in 1987, the United States created more stringent rules on what types of businesses qualified for the tax benefits of MLPs. Then in 2006, Canada removed the tax benefits of a royalty trust, a structure akin to a U.S. MLP.

In 1987, following a proliferation of publicly traded partnerships, the U.S. specified the types of businesses that qualified for MLP tax-deferred status. PTPs that did not qualify had 10 years to meet the requirements or switch to corporate status. In 1997, these partnerships were given a further option of paying 3.5% tax on gross income, which some elected to do.

In 2006, Canada changed its energy trust rules (which previously provided for little or no corporate taxes), so that they would be subject to the statutory tax rate of 28% beginning in 2011. Share prices of Canadian energy trusts immediately dropped 30% after the announcement, but gradually recovered. Over the next few years, most trusts merged or liquidated and eventually converted to tax-paying corporations. For the most part, former trusts have fared poorly since the new tax rules took hold in 2011, but we attribute this largely to business mismanagement rather than any direct impact of paying taxes. In particular, many ex-trusts attempted to pay yields similar to those of the past era--despite a lack of favorable tax treatment--while dealing with unfavorable business conditions, which strained cash flows and balance sheets at the same time. Several former trusts, such as Enerplus and Pengrowth, eventually succumbed to prevailing conditions and halved their dividends in 2012. However, their shares still suffered (share prices are down roughly 60% since their corporate conversions).

That said, it's important to note that in contrast to the volatile cash flows of the Canadian energy trusts (which were exploration and production firms), most MLPs operate in the midstream energy sector, which by design offers less commodity exposure, steadier profits, and more highly visible cash flows available for distribution. A tax code change should therefore be easier to manage in terms of having fewer moving parts. However, we believe the Canadian energy trust example both demonstrates the downside risk for MLPs in a corporate tax scenario and highlights how pivotal a role management can play in navigating industrywide shifts.

Source: http://www.istockanalyst.com/finance/story/6275809/potential-mlp-tax-rule-changes-aren-t-that-taxing

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Potential MLP Tax Rule Changes Aren't That Taxing | iStockAnalyst ...

(By
Connie Hsu, CFA and Jason Stevens) The
Alerian MLP Index sold off nearly 7% in mid-November after the
presidential election, as concerns about the fiscal cliff, budget
deficit, and changes to favorable tax regulations took hold. Beyond
marketwide concerns about pending dividend and capital gains tax
increases, master limited partnership investors seemed concerned that
MLPs may be subject to corporate taxes and new carried interest rules.
These threats--which have existed for years--have been amplified lately
by fears regarding the drastic measures needed to resolve the federal
government's budgetary woes. MLPs, which do not pay taxes at the entity
level, look to be an easy revenue target, but we believe it is highly
improbable that they will see any major changes to their tax-favored
status. In the unlikely event that MLPs became subject to corporate
taxation, however, we'd expect only a modest impact on valuations.

Removal of Congressional Support Unlikely
Master limited partnerships have enjoyed pass-through tax status since the Tax Reform Act of 1986, which was designed to encourage private investment through a lower cost of capital. MLPs pass through their income to unitholders, who then pay taxes on that income at their own marginal tax rates often only when the units are sold. MLP income is therefore taxed only once, in contrast to the double taxation that happens when corporations pay entity-level taxes on income and shareholders pay a second layer of taxes on dividends received.

MLP investors therefore pay less tax overall, but the difference is not significant enough for the government to pursue, in our view. In early 2012, Congress estimated that taxing energy MLPs (with a combined market capitalization of more than $300 billion) at the corporate tax rate of 35% would generate only $300 million in annual revenue. The low tax yield is largely due to the nature of midstream businesses (which constitute the majority of MLPs); they employ heavy fixed assets that garner a large depreciation deduction in the calculation of taxable income. Because the gain is trivial relative to other potential tax revenue sources, we do not believe Congress will pursue this route.

Moreover, additional taxation would jeopardize private investment in the development of domestic energy resources and potentially force even costlier public investment over the long term. MLPs have gained bipartisan support, as they have proved very successful in financing and building out energy infrastructure over the years, in line with many political agendas that seek lower energy costs for consumers, domestic energy independence, and jobs growth. In recent congressional testimony, the National Association of Publicly Traded Partnerships, the industry lobbying body, noted that MLPs supported an estimated 323,000 jobs in the midstream energy sector and invested an estimated $17 billion in domestic energy infrastructure during 2011.

To this end, the most recent changes to MLP tax rules have actually expanded the potential base for MLP qualifying income to include transportation and storage of biofuels and other liquids, in support of their development. Likewise, the latest MLP proposal (the Master Limited Partnerships Parity Act introduced this past June) targets further expansion of the MLP umbrella to include renewable energy activities, while the latest fiscal cliff deal (the American Taxpayer Relief Act) extends and increases tax subsidies worth an estimated $12 billion over 10 years to wind energy companies.

What Could Change in the Short Term?
Of all tax reforms, the two most likely are changes to the treatment of dividends/capital gains and carried interest.

The just-passed American Taxpayer Relief Act increases the dividends/capital gains tax rate for high earners (annual household income of greater than $450,000) to 20% from 15%. Over time, this higher tax rate could apply to a larger population if the income threshold is lowered to the originally proposed $250,000. Broadly speaking, the higher the dividend taxes, the more attractive the tax-deferred status of MLPs appears to investors, when compared with corporations. Because distributions are not taxed as dividends, MLP investors pay less in total taxes on net income.

We do not believe treatment of carried interest in publicly traded partnerships will affect energy MLPs at all, as the proposal targets financial services firms that are structured as publicly traded partnerships. Carried interest refers to the share of profits that partners receive for profitable investments, which under partnership taxation rules is taxed at the long-term capital gains rate. It's been an issue lately because hedge fund and private equity managers, who receive much of their compensation through this carried interest, effectively pay only lower capital gains taxes on this compensation, rather than higher ordinary income taxes. Proposed legislation seeks to treat the carried interest of financial services firms as ordinary income. Though this does not affect MLPs generally, it could have some impact on publicly traded general partnerships, as incentive distribution rights could become taxable as compensation and hence be subject to ordinary income taxes. However, the language of the current bill specifies these changes for financial services firms, so energy MLPs would be excluded. Additionally, MLP unitholders already pay taxes at full ordinary income tax rates. Hence the potential revenue gain for the government from corporate taxes comes at the expense of losing the taxes that partnership unitholders currently pay. This is another reason the incremental gain of taxing MLPs is less than expected at first glance.

What Could Change Over the Long Term?
Over the long term, we believe a greater overhaul of tax policy is fully possible. Potential changes could take several very different flavors, affecting both corporations and MLPs. There are several proposals that we believe would significantly affect MLP investors, including shareholder credits for corporate taxes paid; corporate deductions for dividends paid; shareholder exemptions for dividends received; rate alignment (investor tax rates on dividends and capital gains on sales of corporate stock would be reduced as a partial offset to the additional tax at the entity level); and lowering the maximum corporate tax rate while broadening the tax base applicable to the tax.

While we cannot precisely show the impact of each proposal, we note that overall these efforts seek to eliminate or reduce the double taxation of corporate profits at the entity level and shareholder level. Should such reforms pass, the tax revenues from MLPs and corporations would therefore be much more comparable.

Valuation Impact to Morningstar's MLP Coverage

Though we view the probability as remote, it is possible that the MLP structure could be eliminated. It is difficult to precisely forecast the impact to the sector without knowing the specifics, but to get a sense of how valuations and structures could change, we make a few simplifying assumptions to generate a worst-case scenario.

We assume the MLP structure dissolves, businesses convert to corporations, and income is subsequently subject to corporate taxes at the 35% statutory rate. However, the C-corps under our midstream coverage realize an average effective tax rate of 25%, and hence we use a 25% effective tax rate in this scenario. We assume Congress provides a grace period, comparable to historical precedent of three to four years (depending on when the legislation is passed), so corporate taxation begins in 2016.

This higher tax rate is somewhat offset by the lower implied weighted average cost of capital. The taxes paid now reflect an interest tax shield previously unrealizable for MLPs. We maintain the capital structure mix of about 50% debt financing and 50% equity financing in this WACC assumption and in our financial forecasts through 2016. Realistically, we'd expect companies to shift toward greater use of debt financing over time, but for our simplified scenario, we maintain the current mix.

In our discounted cash flow models, we reduced terminal enterprise value/EBITDA multiples by 2 full turns to reflect the average premium at which midstream MLPs currently trade to midstream C-corps. We attribute the premium primarily to the structural tax and capital cost differences between MLPs and corporations, which we extract in this scenario.

We assume that general partners of MLPs dissolve as soon as administratively possible, probably before corporate taxes begin in 2016. This could happen in several ways--through the conversion of GP units to LP units, a cash buyout of the GP, or vice versa. For our worst-case scenario, we assume the first option, that GP units convert to LP units at revised fair value estimates after applying taxes in perpetuity and a lower WACC. In reality, this unit conversion may not take place at fair values, but instead at a discount to market pricing upon announcement. This therefore implies that publicly traded general partners dissolve after receiving LP units as compensation. In our coverage universe, this applies to NuStar GP Holdings and Energy Transfer Equity.

Assuming a gradual shift to corporate status, we'd expect distributions to be cut dramatically, as capital structures shift to reduce reliance on the capital markets for growth financing (a hallmark of the MLP model). With lower expected free cash flow, firms would probably slow expansion and hold on to more free cash flow in order to internally finance growth, rather than routinely issue follow-on equity, in particular. This would curb growth expectations (from current average annual growth rates of about 5%) making these former MLPs less attractive to yield investors.

Our worst-case scenario does not incorporate these growth factors, as we believe they are strategy changes that are likely to vary significantly, depending on company-specific considerations such as existing capital structures and growth prospects.

Given our simplification of the MLP transition process, our estimates should be taken with a large heap of salt. However, we still find the exercise interesting for a few reasons. In particular, we were able to derive some general observations about what types of MLPs would see the most impact and the least, which provides some insight into current capital costs across our coverage universe. This type of comparison is not easily observed because of the different MLP structures in existence, given the range of general partner incentive distribution rights, international taxes, subordinated unit issuances with particular rights, and excess cash flow cushions. In particular, this taxation exercise effectively removes a major difference in capital structures (general partner incentives) and puts capital costs on a more level (albeit still uneven) playing field.

In this tax-affected scenario, the impact is significant but not devastating by any means. Our fair value estimates fall an average 14% as a result of corporate taxation, and we observe a few trends.

A lower weighted average cost of capital benefited all companies modestly, adding an average 4% to fair value estimates. On average, our WACCs decreased by 70 basis points, to 7.3%, thanks to the inclusion of tax shield benefits.

Raising the effective tax rate by 25% hurt valuations by an average 18% across the board, as a result of lower free cash flow in perpetuity. This makes intuitive sense, since for our coverage approximately 80% of discounted cash flows lie in the perpetuity. As our exercise does not apply taxes to cash flows generated through 2015, we'd expect less than a 25% hit to valuations.

For the MLPs with general partners, eliminating the GP burden generally improved valuations, as some of the tax hit was absorbed by lower GP stake valuations.

Historical Precedents Offer Clues
Though we cannot forecast firm or market reactions to tax changes with much certainty, there is some historical precedent regarding how similar tax legislation changes affected business organizations and the subsequent market reaction. First, in 1987, the United States created more stringent rules on what types of businesses qualified for the tax benefits of MLPs. Then in 2006, Canada removed the tax benefits of a royalty trust, a structure akin to a U.S. MLP.

In 1987, following a proliferation of publicly traded partnerships, the U.S. specified the types of businesses that qualified for MLP tax-deferred status. PTPs that did not qualify had 10 years to meet the requirements or switch to corporate status. In 1997, these partnerships were given a further option of paying 3.5% tax on gross income, which some elected to do.

In 2006, Canada changed its energy trust rules (which previously provided for little or no corporate taxes), so that they would be subject to the statutory tax rate of 28% beginning in 2011. Share prices of Canadian energy trusts immediately dropped 30% after the announcement, but gradually recovered. Over the next few years, most trusts merged or liquidated and eventually converted to tax-paying corporations. For the most part, former trusts have fared poorly since the new tax rules took hold in 2011, but we attribute this largely to business mismanagement rather than any direct impact of paying taxes. In particular, many ex-trusts attempted to pay yields similar to those of the past era--despite a lack of favorable tax treatment--while dealing with unfavorable business conditions, which strained cash flows and balance sheets at the same time. Several former trusts, such as Enerplus and Pengrowth, eventually succumbed to prevailing conditions and halved their dividends in 2012. However, their shares still suffered (share prices are down roughly 60% since their corporate conversions).

That said, it's important to note that in contrast to the volatile cash flows of the Canadian energy trusts (which were exploration and production firms), most MLPs operate in the midstream energy sector, which by design offers less commodity exposure, steadier profits, and more highly visible cash flows available for distribution. A tax code change should therefore be easier to manage in terms of having fewer moving parts. However, we believe the Canadian energy trust example both demonstrates the downside risk for MLPs in a corporate tax scenario and highlights how pivotal a role management can play in navigating industrywide shifts.

Source: http://www.istockanalyst.com/finance/story/6275809/potential-mlp-tax-rule-changes-aren-t-that-taxing

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Thursday, February 7, 2013

Video: Natalie races, Savannah struts catwalk for charity

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Source: http://video.today.msnbc.msn.com/today/50729516/

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Free Ninja Blade, Superstars V8 and more from Green Man Gaming ...

Green Man Gaming is offering a few free PC games this weekend. Starting at 7am Eastern every day from this Friday through Monday, a different game will be free for 24 hours. The first free game will be Zombies. on Friday, followed by Ninja Blade on Saturday, Unstoppable Gorg on Sunday and Superstars V8 Next Challenge on Monday. All told, the offer is worth about 40 bucks.

As you might expect, there is a catch ? albeit a free catch. The first part is obvious: You'll need a Green Man Gaming account. You'll also have to sign up for Playfire, a service that tracks the games you play across multiple platforms (similar to Raptr). Finally, you'll have to link your GMG and Playfire accounts.

Once that's done, you'll be able to nab each game for free as they become available over the weekend.

Source: http://www.joystiq.com/2013/02/06/free-ninja-blade-superstars-v8-and-more-from-green-man-gaming-t/

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